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Publikationen der letzten 5 Jahre

Groma G, Xin W, Grskovic I, Niehoff A, Paulsson M, Brachvogel B, Zaucke F (2012) Abnormal bone quality in COMP and matrilin-3 double deficient mice caused by increased TIMP-3 deposition and delayed aggrecan degradation. Arthritis Rheum. 64: 2644-2654.

Kim DS, Li KW, Boroujerdi A, Yu YP, Deng P, Zhou CY, Park J, Zhang X, Lee J, Coupe M, Sharp K, Steward O, Eroglu C, Barres B, Zaucke F, Xu ZC, Luo ZD (2012) Thrombospondin-4 contributes to spinal sensitization and neuropathic pain. J. Neurosci. 32: 8977-8987.

Bechtel M, Keller MV, Bloch W, Sasaki T, Boukamp P, Zaucke F, Paulsson M, Nischt R (2012) Different domains in nidogen-1 and nidogen-2 basement membrane formation in skin organotypic cocultures. FASEB J. 26: 3637-3648

Agarwal P, Zwolanek D, Keene DR, Schulz JN, Blumbach K, Heinegard D, Zaucke F, Koch M, Krieg T, Paulsson M, Eckes B (2012) Cartilage Oligomeric Matrix Protein (COMP) – Evidence for a role in regulating skin extracellular matrix suprastructure. J. Biol. Chem. 287: 22549–22559.

Widmer C, Gebauer J, Brunstein E, Rosenbaum S, Zaucke F, Drögemüller C, Loeb T, Baumann U (2012) A molecular basis for the action of the collagen-specific chaperone Hsp47/SerpinH1 and its structure-specific client recognition. Proc. Natl. Acad. Sci. 109: 13243-13247

Lowin T, Weidler C, Jenei-Lanzl Z, Capellino S, Baerwald CG, Buttgereit F, Straub RH. Relation between placental growth factor-1 (PlGF-1) and vascularization, DHEAS to DHEA conversion, or aromatase expression in patients with arthritis. Arthritis Rheum. 2012;64:1799-1808.

Hamann N, Zaucke F, Dayakli M, Brüggemann GP, Niehoff, A (2013) Structural, biochemical, and mechanical properties of the functional bone-cartilage unit in relation to growth. J. Anat. 222: 248-259

Brachvogel B*, Zaucke F*, Dave K, Norris EL, Stermann J, Dayakli M, Koch M, Gorman JJ, Bateman JF, Wilson R (2013) Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome. J. Biol. Chem. 288: 13481–13492    * shared first author

Zeng J, Kim D, Li K-W, Sharp K, Steward O, Zaucke F, Luo, ZD (2013) Contribution of thrombospondin-4 to spinal cord injury induced pain states. Eur. J. Pain 17: 1458-1464

Retser E, Schied T, Skryabin BV, Vogl T, Smyth N, Hamann N, Niehoff A, Herrmann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent P, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V (2013) Inducible expression of transgenic human TNFα in adult mice develops psoriatic-like arthritis. Arthritis Rheum. 65: 2290-2300

Bell PA, Wagener R, Zaucke F, Koch M, Selley J, Warwood S, Knight D, Boot-Handford RP, Thornton DJ, Briggs MD (2013) Comprehensive analysis of the cartilage proteome from three different mouse models of chondrodysplasia reveals both common and discrete disease signatures. Biology Open 2: 802–811

Li K-W, Kim D, Zaucke F, Luo ZD (2014) Trigeminal nerve injury induced upregulation of thrombospondin-4 contributes to orofacial neuropathic pain states. Eur. J. Pain 18: 489-495

Hamann N, Zaucke F, Heilig J, Oberländer KD, Brüggemann GP, Niehoff A (2014) Effect of different running modes on the morphological, biochemical, and mechanical properties of articular cartilage. Scand. J. Med. Sci. Sports 24: 179-188

Ruthard J, Kamper M, Renno JH, Kühn G, Hillebrand U, Höllriegl S, Johannis W, Zaucke F, Klatt A (2014) COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins. Connect. Tissue Res. 55: 348-356

Lössl P, Kölbel K, Tänzler D, Nanneman D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A (2014) Analysis of Nidogen-1/Laminin ?1 Interaction by Cross-Linking, Mass Spectrometry, and Computational Modeling Reveals Multiple Binding Modes. PLoS One 9(11):e112886

Jenei-Lanzl Z, Grässel S, Pongratz G, Kees F, Miosge N, Angele P, Straub RH. Norepinephrine inhibition of mesenchymal stem cell and chondrogenic progenitor cell chondrogenesis and acceleration of chondrogenic hypertrophy. Arthritis Rheum. 2014; 66:2472-2481.

Crosby ND, Zaucke F, Kras JV, Donga L, Luo ZD, Winkelstein BA (2015) Thrombospondin-4 and Excitatory Synaptogenesis Promote Spinal Sensitization after Painful Mechanical Joint Injury. Exp. Neurol. 264: 111-120.

Heppner J, Zaucke F, Clarke L (2015) Extracellular Matrix Disruption is an Early Event in the Pathogenesis of Skeletal Disease in Mucopolysaccharidosis I. Mol. Genet. Metabol. 114: 146-155

Zwolanek D, Flicker M, Kirstätter E, Zaucke F, van Osch GJVM, Erben RG (2015) ß1 integrins mediate attachment of mesenchymal stem cells to cartilage lesions. Biores. Open Access 4: 39-55

Bleuel J, Zaucke F, Brüggemann GP, Niehoff A (2015) Effects of cyclic tensile strain on chondrocyte metabolism: a systematic review. PLoS One 10(3):e0119816

Bleuel J, Zaucke F, Brüggemann GP, Heilig J, Wolter ML, Hamann N, Firner S, Niehoff A (2015) Moderate cyclic tensile strain alters the assembly of cartilage extracellular matrix proteins in vitro. J. Biomech. Eng. 137(6):061009

Xin W, Heilig J, Paulsson M, Zaucke F (2015) Collagen II regulates chondroycte integrin expression profile and differentiation. Connect. Tissue Res. 56: 307-314

Jenei-Lanzl Z, Zwingenberg J, Lowin T, Anders S, Straub RH. Proinflammatory receptor switch from Gas to Gai signaling by ß-arrestin-mediated PDE4 recruitment in mixed RA synovial cells. Brain Behav Immun. 2015;50:266-74.

Lorenz J, Schäfer N, Bauer R, Jenei-Lanzl Z, Springorum RH, Grässel S. Norepinephrine modulates osteoarthritic chondrocyte metabolism and inflammatory responses. Osteoarthritis Cartilage. 2015 S1063-4584(15)01290-X.

Jenei-Lanzl Z, Capellino S, Kees F, Fleck M, Lowin T, Straub RH. Anti-in?ammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis. Ann Rheum Dis. 2015;74:444-451.

Kamper M, Hamann N, Prein C, Clausen-Schaumann H, Farkas Z, Aszodi A, Niehoff A, Paulsson M, Zaucke F (2016) Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice. Matrix Biol. 49: 132-143

Heilig J, Paulsson M, Zaucke F (2016). IGF1R signaling plays a role in osterix expression and cartilage matrix mineralization during endochondral ossification. Bone 83: 48-57

Schulz J, Nüchel J, Niehoff A, Bloch W, Schönborn K, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F*, Eckes B* (2016). COMP assisted collagen secretion - a novel intracellular function required for fibrosis. J. Cell Sci. 129: 706-716 *shared last author

Oecal S, Socher E, Uthoff M, Ernst C, Zaucke F, Sticht H, Baumann U, Gebauer JM (2016) The pH-Dependent Client Release From the Collagen-Specific Chaperone Hsp47 is Triggered by a Tandem Histidine Pair. J. Biol. Chem. 291: 12612-12626.

Park J, Yu YP, Zhou C, Li KW, Wang D, Chang E, Kim DS, Vo B, Zhang X, Gong N, Sharp K, Steward O, Vitko I, Perez-Reyes E, Wang F, Eroglu C, Barres B, Zaucke F, Feng G, Luo ZD (2016) Central mechansims mediating thrombospondin-4 induced pain states. J. Biol. Chem. 291: 13335-13348.

Stephan A, Batinicy M, Steiger J, Hartmann P, Zaucke F, Bloch W, Fabri M (2016) LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages. Immunology 148: 420-432.

Stoffel W, Hammels I, Jenke B, Binczek E, Schmidt-Soltau I, Brodesser S, Schauss A, Etich J, Heilig J, Zaucke F (2016) Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition. Cell Death Dis. 7: e2488; doi:10.1038/cddis.2016.385

Grässel S, Straub RH, Jenei-Lanzl Z. The sensory and sympathetic nervous system in cartilage physiology and pathophysiology. Chapter 10 in Cartilage Vol. 2 : Pathophysiology. 2016 Book chapter p191-228.

Böhm M, Apel M, Lowin T, Lorenz J, Jenei-Lanzl Z, Capellino S, Dosoki H, Luger TA, Straub RH, Grässel S. a-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients. Biochem Pharmacol. 2016 Sep 15;116:89-99.

Kamper M, Paulsson M, Zaucke F (2017) Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop. Cell Tissue Res. 367: 359-367.

Schleich C, Miese F, Müller-Lutz A, Boos J, Aissa J, Nasca A, Zaucke F, Bostelmann T, Schimmöller L, Steiger HJ, Antoch G, Bostelmann R (2017) Value of Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage for the Perioperative Assessment of Cervical Intervertebral Discs. J Orthop Res. 35: 1824-1830.

Bostelmann R, Bostelmann T, Nasaca A, Steiger HJ, Zaucke F, Schleich C (2017) Biochemical validity of imaging techniques (X-ray, MRI, and dGEMRIC) in degenerative disc disease of the human cervical spine-an in vivo study. Spine J. 17: 196-202.

Firner S, Zaucke F, Michael J, Dargel J, Schiwy-Bochat K-H, Heilig J, Rothschild MA, Eysel P, Brüggemann G-P, Niehoff A (2017). Extracellular Distribution of Collagen II and Perifibrillar Adapter Proteins in Healthy and Osteoarthritic Human Knee Joint Cartilage. J Histochem Cytochem. 65: 593-606.

Schmidt KG, Herrero San Juan M, Trautmann S, Berninger L, Schwiebs A, Ottenlinger FM, Thomas D, Zaucke F, Pfeilschifter J, Radeke HH (2017). Sphingosine-1-phosphate receptor 5 modulate early stage processes during fibrogenesis in a mouse model of systemic sclerosis: a pilot study. Front Immunol. 8:1242.